Aging in the Age of Today
š¤·āāļø ESTIMATED READING TIME: ONE HUNDRED AND TWENTY SIX MINUTES
Disclaimer:
Everything below is a mix of what I observed and heard during the event. The goal isnāt to pinpoint "who exactly said what," but to share (usually) an outsider's view and overall perspective on these industries. Iām not here to act as a definitive firsthand sourceāreaders should do their own research. I hope this inspires you to attend events, explore new industries, and hear what leaders are presenting. These notes combine my observations with thoughts on how things could run smoother and how ideas connect (IMO). Iām not an expert, you know? Just hanging out in the room with them. Enjoy!Topics Covered: Aging, Science, Data Testing, Basically Cloned Virgin Mice, Pre-Aged Mice, Sex Difference in Aging, Measuring Frailty, Trends in Health, Early Life, Clinical Norms
Are you getting older? Me too! Right now, actually. So, letās learn whatās going on. Will lotions solve aging? Good nutrition? A pill? Magic? Iām so curious to hear what is discussed at this event hahaha. I am extremely ābehind the timesā in the topic of āagingā. I guess that makes me āyoungā in āaging-knowledgeā years, huh? Itās like dog-years.
Why Attend: Lunch? Learn? Yes! Two of my favorite things. Iām usually not hungry in the mornings, but by lunch - Iām itching for a bite. Plus, I want to live to be 140+. Just seems like if you play your cards right, itād be not too bad. I hear so many people in their 60, 70,80ās say they feel better than they did in their 30ās. And into my 30ās, I feel WAY BETTER than my 20ās - most days. As long as I keep active. So, Iād like to hear more and keep building momentum to a wonderful long life of purpose š. Letās glow up with the topic of growing up.
Overall Event Ratings: Venue (4/5), Food (4/5), Speaker Content (4.5/5), Networking (4/5), Likeliness to Return (5/5)ā¦ (more below)
Photo Collage and Commentary:
Notes from the Event:
TRAVEL:
The ride there was fun/funny - for the start, I saw it was maybe raining the moment I got outside, so then I ran back up the all of the stairs to grab my raincoat (which ran me late for the bus) so I took a lyft to the further-ahead station.
Then, the funny thing with the lyft driver is that AT first, a DIFFERENT lyft driver tried to pick me up, but I shooed him away cause his license plate said 30 not 31, so it was close, but not quite. Not my car- Shoo!
Then moments later I saw he was going to pick up another lady close by who was trying to get MY lyft driver. Then the two lyft drivers waved to each other, laughing over ālyft driver confusionā or whatever. THEN I got into the correct car, laughing.
THEN I told my driver the story when I got in, how his car said 30 but the other said 31 so it wasnāt him. THENNNN HE TOLD ME THAT GUY, the other driver - WAS HIS COUSIN š. AND he didnāt know their license plates were only one number apart hahahahah. Wild.
Then, I took the subway, then ran to the bus - got it within seconds!! Then, ended up arriving way too early, hahaha. So I got a mango at a local market that I LOVE (I like grocery stores that prioritize local food) and sat down to chill. The mangos were $3.49 EACH - and they were ALL different sizes, so I picked one of the biggest ones. Duh!
Plus, Iāve been learning more about the ānumber codesā on foodā¦ if it only has four numbers.. four = youāre (eventually dead) on the floor! Try to avoid produce with only four numbers, that indicates itās 100% chemical dependent.
Then ones that start with ā9ā you can wash away the chemicals.
(I think) the more numbers the better.
And this market also had some chalk and then like a solar-reactant art toys . So I grabbed a few here.
Lately, my daughter is really wanting more creative activities. So, I try to involve her with cooking her own meals, cleaning, kinda everything we try on her own (with my assistance).
I want us to start doing more hands-on crafts next.
Especially now that the weather is nice. We can have fun with chalk.
BUT WAIT - hahahha. As Iām about to retype up my notes RIGHT NOW, Iām back at the market/grocery store typing/working again- (was here before and after the event) - and now this guy (about my age) just dropped his MASHED POTATOES off of the side of the stairs!!!!! š They just fell down off the stairs and crashed onto the floor, almost hitting me and a grocery store employee!! It was so funny and insane/out of nowhere.
Heās on the speakerphone, going down the stairs, holding onto a to-go sushi box, and then a bowl of mashed potatoes on top. But then the bowl falls off and crashes through the dividers of the stairs and onto the floor right by me.
Then the guy goes, shouts to the person heās speaking to on his speaker phone, āOh MY GOD!! I JUST DROPPED MY MASHED POTATOES, I JUST DROPPED MY MASHED POTATOES DOWN THE STAIRS, let me call you right back - let me clean this up. Let me call you right back!!ā Then his friend comes up, he hands his friend the sushi box, and he comes down to clean up the mashed potatoes.
I told the story of what had happened to a mom and her two kids that had come and sat next to me. They were wondering what had happened and the guy was taking a while to come back and clean it up. So, I retold it all to them dramatically, to those kids too hahaha. Cuase the mom was nice and I know kids like dramatically told stories. I said how he was like, āI JUST DROPPED MY MASHED POTATOES DOWN THE STAIRS!!ā Repeating it, on speakerphone, it fell off his sushi box!! Then his friend came over!! hahaha.ā
Soon, he arrives. Heās running over with so many napkins in hand, apologizingso much. I said its no problem. It was so funny. He starts whiping up all the potatoes into a little tent shape to then pick them up, and pick them off the floor. But its not easy to clean up. I mention that to him, how mashed potatoes are super hard to wipe off this floor, huh? hahah
Then he apologized to me again and I told him, again, it was hilarious. He said it was raining mashed potatoes. And I told him that Iād never heard someone say that sentence before, he said, āwhat? Itās raining mashed potatoesā - and I said, no āI just dropped my mashed potatoes off the stairsā it was so funny.
I told him that I think āraining mashed potatoesā is a book, lol. He said, no, raining tacos. I said, idk.
He said, āIts a good way to pickup someone. Just drop mashed potatoes as an excuse to talk to themā. I told him, yes, he should try that on someone, sometime. Itās a good one hahaha. Then he brought it up again!! And then I told him Iām not single and he said yeah, he was joking. He didnāt mean it THEN/THERE literally.
Then he stopped cleaning and he said the grocery store staff was coming to clean up the rest of it and he walked away. hahaha - but theyāre still not here (the staff) hahahaha. But the family of three was still here, next to me the whole time. They got a lunch and learn, too.
OKAY the notes:
Okay, so down the street, I walked a bit to get to the venue (cause once I realized I was so early, I found a place to chill- that marketā¦ and I had a meeting after, so I planned to go back after). I walked past the HQ of a MEGACORP! THere were so many fancy cars. Made me wonder if it was worth it. I also saw a pregnant girl who smiled at me, she was holding her huge stomach. I cheered her on: hang in there! She said āthank youā sincerely haha. I jsut remember being at that stage and everyone felt too āPCā to ask if i was pregnant or even help or encourage me or notice. Like my whole pregnancy I think 3 people commented!!!!!!!!!!!! Itās something you sorta look forward to. Or I did. So I was surprised it never happened.
And it seemed like she worked for one of those companies - and was legit looking STUNNING!!! so I was just like, dang girl! You are doing it hardcore right now.
And then I arrived at the venue. The doors were locked for āsecurityā but they quickly let me in. Then I grabbed some food, went through more security doors, and grabbed a seat.
and btw - THIS EVENT WAS FUNNY hahaha (and, again, this event was BEFORE the mashed potatoes hahahah). Idk how it had so many jokes (really, sometimes the most data-packed talks always end up having the most jokes). Lots of the jokes were by the audience in this one, too. It was really nice.
Also, It didnāt feel like an appropriate setting to be typing rapidly (it was only like 10-20 people at this event, small room, lunchā¦), so I took notes in my notebook w/ a pen. Oldschool style!
But, from this event (and talking to the speaker before hand) I realize Iām finding a lot of trends among industries, a lot of exciting opportunities and some need. Iām really getting excited as I attend more events and understand āresearchā, āhealthā, and āinformation gatheringā better. I think we have a lot of amazing potential and breakthroughs coming across lots of industries - especially science/food/health.
And with that!! Letās get LETS FINALLY into my notes.
LUNCH (cause itās LUNCH and LEARN)
At lunch, I ended up sitting next to the speaker. This made me nervous cause I really wanted to like her. I donāt want to sit down next to someone, not like their personality, and then hear them speak ->>> AND THEN WRITE ABOUT IT!!!!!! Those stakes are so high! You know? And weird!
But not sitting at that table felt rude/weirder. There werenāt many seats and I didnāt want to sit at this 4-person table with one chair left and just 3 men my age sitting there together (they all looked like friends, too). Nooooo. hahahhaa. And then there was a table, empty, besides those ladies!! Thatād be so rude too, hahaha.
So, I sat with three nice seeming ladies and quickly told the one I sat next to, that I even recognized her from the photos, sheās the speaker. She agreed ,as she was introducing herself, hahah. I liked her vibes and I liked the conversation I walked into.
She had been saying in her industry, there are a lot of people looking into it for weird reasons, even snakey (she said), so sheās really cautious of them. I liked this. I liked how sheās skeptical and just says it how it is. I donāt know a lot about this industry, but I know snakes are in ALL industries.
So, the fact she acknowledges it, works against it. I liked it. Would we have the same definitions of āsnakeyā? No clue!!! But opinions can change and intentions are important. I think it just made me happy to hear she has a strong heart and values and is careful with her work.
Plus, I want to attend events and leave happy/hopeful. I want for updates from health, science, etc to be great news that we keep moving forward. Problems solved!!
Okay, Iām rambling, but I was like, okay - this girl is cool
Then we talked a lot more. We talked about each individualās role these days to speak up, share, and stand up. I told her how I write little blogs about events and try to make content teaching. But we all can only do so much, yet Iām feeling so optimistic.
There is new money coming into these forgotten sectors (like her own) so we must work to brand and communicate these important innovations. How lucky this time is!! To make money off these solutions that benefit everyone. AND we need money - but not a lot. She said 10M would be plenty. Seemed from her reaction 1M would be pletny. Just need to help her explain to investors why this is important (and Iād like to know more of the science/alright, whatās REALLY going on here?). Get people on-board with solving problems.
We talked about a conference Iām speaking at next month - itās for regenerating earth with a focus on finance and investing. I see this happening.
With all the government funding cuts, itsā up to āthe peopleā now to supply the resources.
In one way this is bad - but in another, look at the āagricultureā industry - they said the government only pays for corn and soy. So if we know we canāt depend on the government, maybe thatās a good enough excuse for some people/investors to step up and try investing in these little solutions. Or experiments. Not just depend on the government grants. We need individuals to step up. Itās time to step up.
One lady said family offices are becoming more popular than ever lately, a lady at my table.
I know those bring up a lot of raised eyebrows in the āactivist investorā community.
AND btw - Speaking of the āactivist investorā community - right before I went to the event, (while eating that mango in the market, I saw that LARRY CHENG had tagged me in my reply to his post!!) So, my mood was soaring š
I enjoyed talking with the soon-to-be-speaker a lot. She was talking with the ladies at the table about how theyāre discovering even some bugs have qualities to them (like some chemicals or whatever) that are showing signs of anti-aging, but they need to do more testing. WHAT THE HECK!!! hahaha - Iām like, Iāll eat a cricket if it slows down my aging!! Every day! hahaha.
Also, I like how she was talking about this really casually/seriouslly, among her peers. It didnāt feel salesy or like āpreachyā it was more just like, āguess what? bugs cure aging.ā - sharing an interesting fact that sheās excited about and a little disappointed to see its not catching on. And Iām like, āOMG shouldnāt the whole world be looking into this fact!?ā
But she said YEAH - (cause later I talked with her about it) but she said they apply for funding for stuff for like this all the time and it always gets shot down. Itās all grant-dependent. I told her maybe itās like āagriculture worldā where only ācorn and soyā are funded. The rest are on their own. She didnāt reply cause it was time for her speech.
So yeah, I think there is a lot to this and maybe more than weāre able to research at the moment -because of lack of funding and a sorta broken system.
I think thatās why this funding is being all reworked in the government. Then hopefully redistributed and then we reorganize our entire system to be more efficient. I kinda feel/hope thatās what happening, but weāll have to see it to believe it.
I was lucky to spend so much time talking to her in āmy languageā before her presetnation, at my level of understanding, about āsociologyā the āpersonās roleā, industry roadblockers, etc - cause her speech was pretty āindustryā speech. But still realllllyyy interesting. Learned a lot - and the audience was a RIOT!!!
hahah everyone was making jokes nonstop. It was so nice.
Alright, let me write down my notes below. hahahahh. I am not sure if Iāve left that sentence in this blog (or deleted it each time) but i feel like I wrote that like 3 or 4 times by now, but I keep wanting to say other stuff too hahahahah. Okay. NOWWWW let me look back and forth from my notebook to my laptop here in this grocery store where there are still mashed potato leftovers on the flooorā- and share what I learned.
BTW somehow mashed potatoes eventually just like, fade away. The color disappeared over the hour(s) and you couldnāt hardly see them by the time I left. Now I realize that I could/should? have cleaned them up? But, when I left they were almost invisible. So, I felt like it was sorta a tattoo for the floor of that memory/moment.
NOTES FROM THE PRESENTATION
Intro: IDK what it was about this intro but the EMCEE nailed it today. Iāve seen her speak a few times before (and even host conferences hahahah) but she was 100% in the zone today and was so funny. Her start to this speech kicked off our speaker into a great start.
This group hosting this is a nonprofit for tech. They wanted to be sure this region could deliver much like Silicon Valley does to its innovators.
They want strong entrepreneurs and a strong community of intelligence and tech.
They want to bring together private, academic, and public money to advance innovation.
UW is the top government funded university in the country!! With these recent cuts entire schools have been wiped .
WOW! But I instantly think of the Ai self-driving car presentation I went to. Where these cars are being build and the tech is being trained, but so much is dependent on STUDENT RESEARCH!!!!!! And the students leave or graduation - then the data. PLUS!!! WHEN I WAS A STUDENT I WASNāT DOUBLE OR TRIPLE CHECKINGā- ARE THESE STUDENTS!?!??! Sometimes I wasnāt even single checking. Clearly.
Basically, I canāt believe how entire industries base so much on STUDENT RESEARCH. So, perhaps relooking at this system and changing things up WOULD NOT be the worst idea hahaha. But maybe thats how it is worldwide!! IDK. CHATGPT - deep research this for me, will you?
They believe there is a need for the public to step in and support public research now more than ever.
ha!! we talked about that at lunch. Me and the woman about to present. How we all have to step up and play a role.
Special reports on learning from calamity and preparing for the next k-12 shutdown.
Wahhh! haha. Why do we need to prepare for this again? What is coming? lolā¦
They want 100 startup to be showcased at their next event. Even though the price looks expensive, she can give you a good rate if you just ask. hahahah.
She says they will, then have a huge lunch-in for a bunch of people and then host some huge leaders in the region.
Now, the event leaders are in a competiton (these leaders of corporations) to outdo each other in attendees (this is an event Iām not going to attend btw)
Their desire to have more attendees is a ājokeā, but it also taps into something I heard lately. Like a way to distract a culture is to get them obsessed with āfollowsā so that they never can be happy. Turns out even the CEOās of our worldās top companies deal with desire too, apparently.
Cue: Sheās so lucky. Sheās a star but she cry cry cries in her lonely heart. Thinkinā. If thereās nothinā missing in my life - then WHY DO THESE TEARS come at night??
Lost in an image. In a dream, but thereās no one there to wake her up. Yeah the world is spinninā and she keeps on winninā. But tell me - what happens when it stops? They go. Isnāt she lucky this (lol i dont even wanna put the next words in writing so many times ) hahaha - letsā keep going. But yeah, was vibing. Love that song.
WELCOMING THE SPEAKER ON STAGE, INTRODUCING THE TOPIC
LOL the emcee makes a joke: With my cheerful most optimistic estimate of how long I will live, Iām on the backside of that curb.
Good joke / wording - but NO, GIRL!! Live it up! hahah join me!! Letās be 130+, lovinā life!! hahaha. Everyone!! Letās believe in ourselves and advancements in nutrition and the future hahaha. Not giving up alreadyyyy.
But for real, I liked her intro and her jokes. Seems like this was a well-prepared event. Not a HUGE turnout, but fine and interesting.
I also loved the speaker already, like, just to be dramatic hahaha. Just from our lunch talk, I was like, okay. I am supportive of her thought process and caution of our world.
SHe says: This audience isnāt scared of data. Hope youāre not too afraid. We will sort through it all together.
Her company is ENTIRELY GOVERNMENT FUNDED.
wow.
Sheās from australia! Her lab is interested in understanding frailty.
She says sheās happy to be interrupted btw if you have any burning questions
I love that she said this. Itās a good comment to make and really puts the audience at ease. The way she said it too, you know she meant it. So, it worked. The audience was insanely engaged this entire time.
AGING: What we will cover
How do you measure aging?
Frailty assessments in mice
Kane law (this part I was pretty tuned out btw - warning. It got techincal, but still learned a lotā¦ the ācloned miceā as a standard that youāll hear about in part 2 had my mind pretty preoccupied from thereon out)
The more you age, the more likely your risk of almost every disease, especially after 85 years old.
Heart disease is the most common, cancer is second.
If we can figure out the cause of aging, we can prevent all of these diseases.
An audience member speaks up: Once someone is older and they start to get sick, it can last up to three years at most until they die, right?
See!? Instant this-speech-is-alive experience, itās the speaker AND the audience. What a convo weāre about to have!! hahah. And what a funny question!! āPeople only stay sick for 3 years most (then die)?ā This was asked by an adult man!
No there are all sorts of diseases people can acquire which last decades. Althesimers, etc, midlife diseases.
Plus, we have decent medical treatment these days, too, so this can manage the pain and extend a personās life.
eek-ish.
We donāt want to only increase the lifespan if itās while you are suffering. We want to try to increase the lifespan of the time youāre healthy.
yeah!! glad she said that :)
There are 12 hallmarks of aging. Everything she lists is (idk?)
You can start to lose your senses when you get older!! Your 5 senses will fade. Lots of things :(
So how do we increase our healthiest time and delay aging?
We donāt have any good ways of measuring aging itself.
OMG THIS GRAPH SHE POSTED IS FREAKING ME OUT!!! hahah. MY PLANS OF LIVING TO 140+ ARE NOT LOOKING GOOD HEREEEEEEEEEE.
We maintain health and then there is a period of decline.
There is a lot of biology in healthy
if we use choronologocal ages, we get variety. Some people are robust at 80, some people are severly frail.
I will continue to be robust!!
They test with controlled, inbread mice strains.
CONTROLLED INBREAD MICEā¦ STRAINS!? like āliko and and smitchāā¦ š
With the mice strains, they get a lot of variety.
In older age, some are robust and lively, some become frail quicker and lose function.
Measuring is a big undertaking. Their age doesnāt determine their abilty to function. It happens to each inbread mice at different times.
How do we say where someone is on the aging curve?
The chronolical age doesnāt give enough data.
Your variability from the average will tell you about your health. If youāre aging faster or slower than the average.
Some evidence can show this is true, but the evidence isnāt super strong yet.
Alright, alright. Iāve heard this many times beforeā¦. the classic scientist sentence. So, Iāll let it slide a few times this talk. You brought it up at lunch with the bugs, now this tooā¦
Some of these less traditional factors shoudl be studied, but this current administration doesnāt agree.
Seeā¦ I am here to figure out whatās going on?? What do we need to put money into? hahha - bugs? MORE INBREAD MICE!?!?!?!
Some of the reasons that mice may age quicker than others (even though theyāre inbread strains!)
Not a lot of opportunity to exercise inside their cages.
The male mice have serious social-heiarchy anxiety.
Maybe they were part of a smaller or bigger litter.
Were they from the the first, second, third, etc. that the mom had given birth to?
What was their early life like?
Tests are conducted by humans about their deficiencies.
The EMCEE hollers out: Are they reported by myself or by my husband? Cause if soā¦
She is jokinā š
Self-reported tests measure body performance with age. These scores are added up and indicate frailty.
Frailty is a way to quantify the heterogeneity (i.e. variation) in how people experience aging and diseases.
Frailty is the only thing that remains significant in predicting mortality.
So as mice age, they act different. You can see the way their bodies respond in this video (she shows a short video of a child mice wrapping its tail around a pen thatās held near it. Then an older mice doesnāt wrap its tail aroud the pen so energetically.)
The emcee (from her chair) asks a comment/question, āI was watching Greyās Anatomy lately and they said they only study male mice because the women are too difficult - is that āa thing''?ā
Everyone cracks up.
We study both.
Everyone cracks up again.
They used to say to āonly study men, because you had to keep in mind the womanās cycleā with their hormones. But itās easy to normalize and track now.
Turns out males actually have more variation in their hormones.
Many people (myself included) gasp!
Female mice groom each other, hang outā¦ the men get into fights!
ahahahhaha. Everyone is losing it laughing so hard (she said more but i was just laughing. More examples of how the male mice are actually a lot more difficult to deal with.)
So, no, that isnāt true what they said on Greyās Anatomy.
-AUDIENCE QUESTION: Youāve used the phrase "āinbread miceā many times now. Monty Python comes to mind and the wild rabbit clone, this and is this capable?
She goes: That definitely happens!
WHAHTHAHHAAAAAAA. THAT DEFINITELY HAPPENS!?!?!?
-AUDIENCE QUESTION CONTINUED: Why use that? (these inbread mice)
Historically, it simplified everything because the genetics. Theyāre basically clones.
BASICALLY CLONESSSSSS
With the C57 strain, you get the crazy mice.
C57 strain, you get the crazy mice!?!??!!
We get aged mice of this strain, pre-aged mice.
WE GET PRE-AGED MICE!??!!
But we get weird results that arenāt representative of humans
There are many sex differences that we can see in the mice as they age too. The differences are consistent in humans and mice.
As the mice get older, there is more variety in females, and females are more frail than males. We donāt know why.
Is this biological or social behavior?
Women are more likely to seek healthcare or report symptoms?
Women seem to even hypothetically have more resiliance
AUDIENCE QUESTION: Do you all test pregnant mice? Or mice who have had babies?
Someone else says, āthat was my next question tooā
Iām like - omg!! not mine - hahahaha. I didnāt even have a next question at the moment!
She says: Theyāre all virgin mice.
Everyone bursts into laughter!!!!
She says: Itās a thing. Itās a term.
Also, in this mouse model, they live shorter. It makes more biological sense than humans.
Then she says, Iāll skip through this next part.
lol (she skips through a slide and then starts talking, but still iām just thinking about all of the stuff sheās said earlier!! It was so much: male mice are more aggressive, they test both sexes, clones, specific strains, crazy virgin mice ā- aaaaaahahahahah!?!!?)
Then I tune back in hearing:
Eating 20-40% less can drastically increase your life span.
š okay?
Machine learning w/ complicated algos can pretty accurately predict ages of mice.
Thatās my pitch on why frailty is the best way we have to measure age.
LOL i love how she was narrating and guiding us through this.
Now, letās look at this next section.
Mouse models and human data. As they age, they get frail.
We donāt have biomarkers to predict, prevent, or delay age.
Frailty is the qualitative outcome. What increases it?
We do a lot of mice work. Mice live to be about three years, so we can look at the entire lifespan.
Except early life, we start studies at 12 months. But now we see
These mice are only tested from ages 12months +, so we donāt research their early life.
12 months is the equivalent of early middle age. We look at their activity, their anxiety levels.
Theyāre in a box box. We track their nesting, burrowing, activities.
We watch their interactions decline with age. Theyāre a very social species.
Theyāre studying the female reproductive aging.
What is happening in the gut microbium? Metabolism? Plasma?
Today we will talk about metabolisms in plasma. Though weāre still waiting on the conclusive data from the inbread mice.
Plasma -> Global Metabolomics
age signature, feature selection, association analogy, sex stratification
Graphs showing lots of variables, all generally decreasing as we age.
What processes and pathways?
Looking at fats in the body. How we process it all.
Many things are sex and gender specific. The maturity of aging signs are very different between men and women. I focus on women most. Males had specific biomarks of aging.
BTW her shirt is really great. Very un-pastel theory. Very lively!!
There are antioxodents found in mushrooms that can be used to measure aging. Analysis says that small amounts of it (too much or too little) can be seen. But itās hard to tell. Itās not clear.
AUDIENCE INTERRUPTS: Okay, so either we need to eat more mushrooms or not too many, right?
Everyone laughs hahahha. Exactly.
Then she goes on to the next slide and apologizes for the part that is in yellow.
Independent of age, look at frailty.
Nicotinate + nicotinamcole metabolisms are gaining media attention as anti-aging elements. But thatās yet to be conclusive.
SEE!! Iām like, girlllll - myself included weāve said that sentence like 5 times now. Hahah. Such a classic āsciencyā line.
Can individual metabolites predict frailty?
And btw, low level frailty = good!
Provide biometics that someone is frail or will become frail.
Preventative is our dream!!
Alpha-keto glucate sodes seem to predic, but itās not concludsive.
Sex-specific extremely varies with metabiometric biomarkers (idk exactly what she said there)
Males and females have completely different sets of markers.
Creatine -> low levels = frailty in men, connected to muscle loss.
Human data saw similar things
Lifestyle intervention w/ relatiely healthy people. Looks at low metabolism group and their change
Seeing similarities in mice with their minds. Fitting into ameno acids.
They want more data in plasma, skin samples, urine, stool, menstrual fluids.
Tons of sex differences vary across entire genes (like, even though theyāre cloning the same genes over and over, remaking the same model of mice, the mice live all sorts of lengths), independent of age.
Looking at the female genital tracts to predict age.
In humans and in mice, the genital samples are older than the blood. This makes sense since they age faster and are one of the first things to go.
OMGGGGG
Specific bugs in the gut are associated with frailty, independent of age.
Look at the entire system and find takeaways.
Ameno acid related metabaloids are associated with aging it may conclude.
Sex is a biological variable.
Okay, so we need not simply ignore these gentle mice the first year of their livesā¦ understood!
They have much to teach us. Cause clearly their early years determine how long theyād live - they only research them one year into life (out of three years) and even though its the same clone, tehy die all different times. WOWWWWWWWW. Nature or nurture? NURTURE? or nature? Hahahah idk. NEXT?
TIME For one question: (a guy asks) Is it true we have one spoonful of plastic in our brains?
Another guy from the audience shouts: itās a tea spoon.
This group is a comedy troupe!!
At the end, she wraps up the presentation thanking everyone who contributed. This really made me light up cause she especially thanked one guy who had contributed to almost every single page. I like how she gave thoughtful thanks.
And legit it was needed, I FOR REAL even almost mentioned it as a joke moments before, but now I see she would have replied, āthatās my next slideā - LIKE A BOSS!
The event is over, the tell us to come back again next month, bring friends.
I talked to a few people after, but then had a phone call / meeting to get to (thatās why I hurried back to the market - then I sat down, had my meeting, then there was the mashed potatoes incident - hahahā¦ and nowā¦ THE END!)
OVERALL EVENT RATINGS Further ELABORATED:
Venue (3.5/5) : Super sunny in this place . Nice lighting and it was a good size for the small but quality turnout! Just really far from me. Took over an hour each way (but super beautiful journey there and back - plus, I can do work on the journey.)
Food (4/5) : It was good! A little dry, like a healthy boxed lunch. Actually, to be fair, EVERY OPTION they had sounded good. So I was really having a tough time deciding. I would have grabbed snacks to go, but I was on my way to a meeting - AND that meeting as at a grocery store (intentionally, they had a good seating area), but I felt like: donāt eat someone elseās snacks in a grocery store, girl!! hahaha. And kept moving.
Speaker Content (5/5) : It was so interesting, time flew, it was super interactive, her slides were filled with info and data. She did the best job teaching people things, while also making it a fun lunchtime break. Her and the emcee rocked it.
Networking (4/5): I kinda always try my best lately to talk to no one and just hang out, work, observe, and then see what sparks/inspires my interest - THEN get into it (sometimes happens instantly, sometimes doesnāt). But this group was very approachable and totally made sure to network with me. hahahaha. So, that was alright.
Likeliness to Return (4.5/5): This is far from me but a nice community and really unlike what you get in many events. Itās a quality lunch and learn - and Iāve been to a few of these series now.
Until next time, I wish you the motivation and success to search for opportunities around your area. Search and explore: Who is out there giving talks? There are new things happening all of the time.
Find relatable or interesting topics you like and check them out! Maybe even something hosted at a cool venue, if thereās no other reason to go. Letās see what you can learn and discover not too far from home. š
